CpG island methylation in sporadic colorectal cancers and its relationship to microsatellite instability.

@article{Hawkins2002CpGIM,
  title={CpG island methylation in sporadic colorectal cancers and its relationship to microsatellite instability.},
  author={Nicholas J. Hawkins and Mark W A Norrie and Kay Cheong and Elisa Mokany and Su-Lyn Ku and Alan P Meagher and T O'connor and Robyn Lynne Ward},
  journal={Gastroenterology},
  year={2002},
  volume={122 5},
  pages={1376-87}
}
BACKGROUND & AIMS Methylation of CpG islands is increasingly recognized as an important event in colorectal carcinogenesis. We evaluated the extent of CpG island methylation in 426 sporadic colorectal cancers to define its relationship to microsatellite instability and to describe its clinicopathologic and genetic features. METHODS Fresh cancer tissue was obtained from 417 consecutive individuals undergoing curative surgery for sporadic colorectal cancer. Methylation of p16 and hMLH1… CONTINUE READING
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