CpG island hypermethylation-associated silencing of microRNAs promotes human endometrial cancer

@inproceedings{Li2013CpGIH,
  title={CpG island hypermethylation-associated silencing of microRNAs promotes human endometrial cancer},
  author={Bi-Lan Li and Wen Wen Lu and Cong Xiang Lu and Jun-jie Qu and Ting-ting Yang and Qin Yan and Xiaoping Wan},
  booktitle={Cancer Cell International},
  year={2013}
}
Endometrial cancer (EC) is the most common gynecologic malignancy, but the molecular events involved in the development and progression of EC remain unclear. This study aimed to explore epigenetic modification of genes and miRNAs involved in EC development. Ishikawa and AN3CA cells were treated with 5’-Aza-2-deoxycytidine or histone deacetylase inhibitor. The expression of miRNAs and related genes were detected by PCR and Western blot. Promoter methylation was detected by bisulfite specific PCR… CONTINUE READING

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Regulatory network of microRNAs, target genes, transcription factors and host genes in endometrial cancer.

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Highly Influenced

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