CpG island hypermethylation-associated silencing of small nucleolar RNAs in human cancer

@article{Ferreira2012CpGIH,
  title={CpG island hypermethylation-associated silencing of small nucleolar RNAs in human cancer},
  author={Humberto J. Ferreira and Holger Heyn and C{\'a}tia Moutinho and Manel Esteller},
  journal={RNA Biology},
  year={2012},
  volume={9},
  pages={881 - 890}
}
Much effort in cancer research has focused on the tiny part of our genome that codes for mRNA. However, it has recently been recognized that microRNAs also contribute decisively to tumorigenesis. Studies have also shown that epigenetic silencing by CpG island hypermethylation of microRNAs with tumor suppressor activities is a common feature of human cancer. The importance of other classes of non-coding RNAs, such as long intergenic ncRNAs (lincRNAs) and transcribed ultraconserved regions (T… Expand
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