CpG domains downstream of TSSs promote high levels of gene expression

@inproceedings{Krinner2014CpGDD,
  title={CpG domains downstream of TSSs promote high levels of gene expression},
  author={Simone Krinner and Asli P. Heitzer and Sarah Daniela Diermeier and Ingrid Obermeier and Gernot L{\"a}ngst and Ralf Dipl.-Ing. Wagner},
  booktitle={Nucleic acids research},
  year={2014}
}
CpG dinucleotides are known to play a crucial role in regulatory domains, affecting gene expression in their natural context. Here, we demonstrate that intragenic CpG frequency and distribution impacts transgene and genomic gene expression levels in mammalian cells. As shown for the Macrophage Inflammatory Protein 1α, de novo RNA synthesis correlates with the number of CpG dinucleotides, whereas RNA splicing, stability, nuclear export and translation are not affected by the sequence… CONTINUE READING
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