CpG-depleted adeno-associated virus vectors evade immune detection.

  title={CpG-depleted adeno-associated virus vectors evade immune detection.},
  author={Susan M. Faust and Peter Bell and Benjamin J Cutler and Scott N Ashley and Yanqing Zhu and Joseph E. Rabinowitz and James Michael Wilson},
  journal={The Journal of clinical investigation},
  volume={123 7},
Due to their efficient transduction potential, adeno-associated virus (AAV) vectors are leading candidates for gene therapy in skeletal muscle diseases. However, immune responses toward the vector or transgene product have been observed in preclinical and clinical studies. TLR9 has been implicated in promoting AAV-directed immune responses, but vectors have not been developed to circumvent this barrier. To assess the requirement of TLR9 in promoting immunity toward AAV-associated antigens… CONTINUE READING
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