CpG-containing oligodeoxynucleotides augment and switch the immune responses of cattle to bovine herpesvirus-1 glycoprotein D.

@article{Rankin2002CpGcontainingOA,
  title={CpG-containing oligodeoxynucleotides augment and switch the immune responses of cattle to bovine herpesvirus-1 glycoprotein D.},
  author={Richard Rankin and Reno A Pontarollo and Susantha Gomis and Brenda Karvonen and Philip Willson and Barbara L{\"o}hr and Dale L. Godson and Lorne A. Babiuk and Rolf Hecker and Sylvia van Drunen Littel-van den Hurk},
  journal={Vaccine},
  year={2002},
  volume={20 23-24},
  pages={3014-22}
}
The adjuvanticity of a synthetic oligodeoxynucleotide containing unmethylated CpG motifs (CpG ODN) was determined in cattle. Calves were immunized with a truncated secreted version of glycoprotein D (tgD) of bovine herpes virus-1 (BHV-1) formulated with alum, CpG ODN, or a combination of both. BHV-1 tgD formulated with CpG ODN or with alum and CpG ODN induced a stronger and more balanced immune response than tgD in alum. This level of immunity was of sufficient magnitude to minimize weight loss… CONTINUE READING