CpG Island Hypermethylation Mediated by DNMT3A Is a Consequence of AML Progression


DNMT3A mutations occur in ∼25% of acute myeloid leukemia (AML) patients. The most common mutation, DNMT3AR882H, has dominant negative activity that reduces DNA methylation activity by ∼80% in vitro. To understand the contribution of DNMT3A-dependent methylation to leukemogenesis, we performed whole-genome bisulfite sequencing of primary leukemic and non… (More)
DOI: 10.1016/j.cell.2017.01.021


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