CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation.

@article{Hcker1998CpGDNAspecificAO,
  title={CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation.},
  author={Hans H{\"a}cker and Harald Mischak and Thomas Miethke and Susanne Liptay and Roland Schmid and Tim Sparwasser and Klaus M Heeg and Grayson B. Lipford and Hermann Wagner},
  journal={The EMBO journal},
  year={1998},
  volume={17 21},
  pages={6230-40}
}
Unmethylated CpG motifs in bacterial DNA, plasmid DNA and synthetic oligodeoxynucleotides (CpG ODN) activate dendritic cells (DC) and macrophages in a CD40-CD40 ligand-independent fashion. To understand the molecular mechanisms involved we focused on the cellular uptake of CpG ODN, the need for endosomal maturation and the role of the stress kinase pathway. Here we demonstrate that CpG-DNA induces phosphorylation of Jun N-terminal kinase kinase 1 (JNKK1/SEK/MKK4) and subsequent activation of… CONTINUE READING
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