CpG DNA and immunotherapy of allergic airway diseases.

  title={CpG DNA and immunotherapy of allergic airway diseases.},
  author={Vipul V. Jain and Kunihiko Kitagaki and J. Nathan Kline},
  journal={Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology},
  volume={33 10},
Atopic asthma is a highly prevalent and serious health problem for which no therapy currently offers the hope of a cure. Preindustrialized and rural populations appear relatively protected from the asthma epidemic; the hygiene hypothesis ascribes this protection to the effects of microbes and microbial products. An important immunostimulant component of microbes is DNA; bacterial DNA contains sequence motifs centred on the CpG dinucleotide, which are suppressed in mammalian DNA… CONTINUE READING


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