CpG DNA and LPS induce distinct patterns of activation in human monocytes

@article{Hartmann1999CpGDA,
  title={CpG DNA and LPS induce distinct patterns of activation in human monocytes},
  author={G. B. von Hartmann and Arthur M. Krieg},
  journal={Gene Therapy},
  year={1999},
  volume={6},
  pages={893-903}
}
A specific set of immune functions is switched on in response to DNA containing unmethylated CpG dinucleotides in particular base contexts (‘CpG motifs’). Plasmids, viral vectors and antisense oligodeoxynucleotides used for DNA vaccination, gene replacement or gene blockade contain immunostimulatory CpG motifs which may have independent biological activity. Although the immune stimulatory effects of CpG motifs on murine cells are well established, the evaluation of their possible effects on… CONTINUE READING
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