Cp*Co(III)-Catalyzed Annulations of 2-Alkenylphenols with CO: Mild Access to Coumarin Derivatives.

Abstract

Cp*Co(III)-catalyzed annulations of 2-alkenylphenols with CO for the synthesis of coumarin derivatives have been developed. The reaction features mild reaction conditions, broad substrate scope, and good functional group tolerance. Preliminary mechanistic studies were conducted, suggesting that C-H activation is the turnover limiting step. Furthermore, the efficiency of this reaction was demonstrated by the rapid total synthesis of three natural products herniarin, xanthyletin, and seselin.

DOI: 10.1021/acs.orglett.5b02728

Cite this paper

@article{Liu2015CpCoIIICatalyzedAO, title={Cp*Co(III)-Catalyzed Annulations of 2-Alkenylphenols with CO: Mild Access to Coumarin Derivatives.}, author={Xu-Ge Liu and Shang-Shi Zhang and Chun-Yong Jiang and Jia-Qiang Wu and Qingjiang Li and Honggen Wang}, journal={Organic letters}, year={2015}, volume={17 21}, pages={5404-7} }