Coxsackievirus-mediated hyperglycemia is enhanced by reinfection and this occurs independent of T cells.

@article{Horwitz2003CoxsackievirusmediatedHI,
  title={Coxsackievirus-mediated hyperglycemia is enhanced by reinfection and this occurs independent of T cells.},
  author={Marc Steven Horwitz and Alex Ilic and Cody Fine and Enrique Garc{\'i}a Rodr{\'i}guez and Nora E. Sarvetnick},
  journal={Virology},
  year={2003},
  volume={314 2},
  pages={
          510-20
        }
}
  • Marc Steven Horwitz, Alex Ilic, +2 authors Nora E. Sarvetnick
  • Published in Virology 2003
  • Biology, Medicine
  • The induction of autoimmunity by viruses has been hypothesized to occur by a number of mechanisms. Coxsackievirus B4 (CB4) induces hyperglycemia in SJL mice resembling diabetes in humans. While virus is effectively cleared within 2 weeks, hyperglycemia does not appear until about 8-12 weeks postinfection at a time when replicative virus is no longer detectable. In SJL mice, reinfection with CB4 enhanced the development of hyperglycemia. As predicted, the immune system responded more rapidly to… CONTINUE READING

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