Coxsackievirus and adenovirus receptor is essential for cardiomyocyte development.

@article{Asher2005CoxsackievirusAA,
  title={Coxsackievirus and adenovirus receptor is essential for cardiomyocyte development.},
  author={Damon R. Asher and Anna M. Cerny and Sarah R. Weiler and James W. Horner and Marilyn L Keeler and Mychell A Neptune and Stephen N. Jones and Roderick Terry Bronson and Ronald A DePinho and Robert W. Finberg},
  journal={Genesis},
  year={2005},
  volume={42 2},
  pages={
          77-85
        }
}
  • Damon R. Asher, Anna M. Cerny, +7 authors Robert W. Finberg
  • Published in Genesis 2005
  • Medicine, Biology
  • The coxsackievirus and adenovirus receptor (CAR) is a transmembrane protein that is known to be a site of viral attachment and entry, but its physiologic functions are undefined. CAR expression is maximal in neonates and wanes rapidly after birth in organs such as heart, muscle, and brain, suggesting that CAR plays a role in the development of these tissues. Here, we show that CAR deficiency resulted in an embryonic lethal condition associated with cardiac defects. Specifically, commencing… CONTINUE READING

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