Coxsackievirus and adenovirus receptor cytoplasmic and transmembrane domains are not essential for coxsackievirus and adenovirus infection.

@article{Wang1999CoxsackievirusAA,
  title={Coxsackievirus and adenovirus receptor cytoplasmic and transmembrane domains are not essential for coxsackievirus and adenovirus infection.},
  author={Xun Wang and Jeffrey M. Bergelson},
  journal={Journal of virology},
  year={1999},
  volume={73 3},
  pages={2559-62}
}
Coxsackievirus and adenovirus receptor (CAR) from which the cytoplasmic domain had been deleted and glycosylphosphatidylinositol (GPI)-anchored CAR lacking both transmembrane and cytoplasmic domains were both capable of facilitating adenovirus 5-mediated gene delivery and infection by coxsackievirus B3. These results indicate that the CAR extracellular domain is sufficient to permit virus attachment and entry and that the presence of a GPI anchor does not prevent infection. 

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A monoclonal antibody specific for the cellular receptor for the group B coxsackieviruses

  • Hsu, L K.-H., K. Lonberg-Holm, B. Alstein, R. L. Crowell
  • J. Virol
  • 1988
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