Coxsackievirus-adenovirus receptor genetically fused to anti-human CD40 scFv enhances adenoviral transduction of dendritic cells

@article{Pereboev2002CoxsackievirusadenovirusRG,
  title={Coxsackievirus-adenovirus receptor genetically fused to anti-human CD40 scFv enhances adenoviral transduction of dendritic cells},
  author={Alexander V. Pereboev and Clement K. Asiedu and Yasuhiko Kawakami and Sai Sai Dong and J. Lloyd Blackwell and Elena A. Kashentseva and Pierre L Triozzi and Wayne A. Aldrich and David T. Curiel and Jackie M Thomas and Igor P. Dmitriev},
  journal={Gene Therapy},
  year={2002},
  volume={9},
  pages={1189-1193}
}
A promising approach to immunotherapy involves the loading of dendritic cells (DCs) with genetic material to facilitate sustained expression of a relevant antigen in this population of potent antigen presenting cells (APC). Viral vectors such as adenovirus (Ad) have been used for this purpose. Existing methods for DC infection are limited by lack of specificity and a requirement for DC exposure to high viral doses. Targeting of Ad to DCs with bispecific antibodies has significantly augmented… CONTINUE READING
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