Coxsackievirus B3 replication is related to activation of the late extracellular signal-regulated kinase (ERK) signal.

@article{Lim2005CoxsackievirusBR,
  title={Coxsackievirus B3 replication is related to activation of the late extracellular signal-regulated kinase (ERK) signal.},
  author={B Y Lim and J Nam and C Gil and Soo-hyeon Yun and Jin Ho Choi and Duk-Kyung Kim and E J Jeon},
  journal={Virus research},
  year={2005},
  volume={113 2},
  pages={
          153-7
        }
}
MAP kinase signaling has been implicated in coxsackievirus B3 (CVB3) pathogenesis and as necessary in the virus lifecycle. We studied the correlation with extracellular signal-regulated kinase 1/2 (ERK1/2) signaling and virus replication in the presence of coxsackievirus and adenovirus receptor (CAR). In CHO cells that do not expressed CAR, specific ERK1/2 phosphorylation (pERK1/2) was not detected, and progeny virus was not produced after infection. By contrast, in HeLa and CHO-CAR cells… CONTINUE READING

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