Coxsackievirus B3 infection and its mutation in Keshan disease.

@article{Ren2004CoxsackievirusBI,
  title={Coxsackievirus B3 infection and its mutation in Keshan disease.},
  author={Liqun Ren and Xiang-Jun Li and Guang-sheng Li and Zhi-tao Zhao and Bo Sun and Fei Sun},
  journal={World journal of gastroenterology},
  year={2004},
  volume={10 22},
  pages={3299-302}
}
AIM To investigate coxsackievirus B(3) infection and its gene mutation in Keshan disease. METHODS The expression of Coxsackievirus B(3) RNA was detected in autopsy specimens of acute (12 cases), sub-acute (27 cases) and chronic (15 cases) Keshan disease by in situ hybridization. In sub-acute Keshan disease specimens, 3 cases with positive result by in situ hybridization were selected RT-PCR analysis. The DNA segments were then sequenced. RESULTS Coxsackievirus B(3) RNA was detected in the… CONTINUE READING