Coxsackievirus B3 from an infectious cDNA copy of the genome is cardiovirulent in mice

@article{Tracy1992CoxsackievirusBF,
  title={Coxsackievirus B3 from an infectious cDNA copy of the genome is cardiovirulent in mice},
  author={Shawn Tracy and Nora M. Chapman and Z. Tu},
  journal={Archives of Virology},
  year={1992},
  volume={122},
  pages={399-409}
}
SummaryA coxsackievirus B3 (CVB3) cDNA clone, upon transfection of HeLa cells, produces CVB3 capable of induction of cardiac inflammation in C3H/He mice by day 8 post inoculation (p.i.). Liver and serum are cleared of CVB3 by day 8 p.i., but CVB3 persists in the heart through day 14. The nucleotide sequence and the predicted amino acid sequence of this clone have sites of divergence from 2 other completely sequenced CVB3 genomes although overall identity of the three CVB3 genomes is 99%. 

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Characterization of an infectious cDNA copy of the genome of a naturally occurring, avirulent coxsackievirus B3 clinical isolate.

  • The Journal of general virology
  • 2005
VIEW 9 EXCERPTS
CITES METHODS & BACKGROUND
HIGHLY INFLUENCED

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