Coxiella burnetii inhibits apoptosis in human THP-1 cells and monkey primary alveolar macrophages.

@article{Voth2007CoxiellaBI,
  title={Coxiella burnetii inhibits apoptosis in human THP-1 cells and monkey primary alveolar macrophages.},
  author={Daniel E. Voth and Dale Howe and Robert A Heinzen},
  journal={Infection and immunity},
  year={2007},
  volume={75 9},
  pages={4263-71}
}
Coxiella burnetii, the cause of human Q fever, is an aerosol-borne, obligate intracellular bacterium that targets host alveolar mononuclear phagocytic cells during infection. In all cell types examined, C. burnetii establishes a replicative niche in a lysosome-like parasitophorous vacuole where it carries out a lengthy infectious cycle with minimal cytopathic effects. The persistent and mild nature of C. burnetii infection in vitro suggests that the pathogen modulates apoptosis to sustain the… CONTINUE READING