Cox-2 inhibitor attenuates NO-induced nNOS in rat caudal trigeminal nucleus.

@article{Varga2007Cox2IA,
  title={Cox-2 inhibitor attenuates NO-induced nNOS in rat caudal trigeminal nucleus.},
  author={Hedvig Varga and {\'A}rp{\'a}d P{\'a}rdutz and Enikő V{\'a}mos and Imola Plang{\'a}r and Eszter Egyud and J{\'a}nos Tajti and Ferenc Bari and L{\'a}szl{\'o} V{\'e}csei},
  journal={Headache},
  year={2007},
  volume={47 9},
  pages={1319-25}
}
OBJECTIVE The aim of the present study was to determine which isoform of the cyclooxygenase (COX) enzyme plays a role in the neuronal nitric oxide synthase (nNOS) activation caused by nitroglycerin (NTG), in the most caudal part of the trigeminal caudal nucleus (TNC) of the rat. BACKGROUND Nitric oxide donor, NTG, can trigger migraine attack in migraineurs, but not in healthy persons. In rats, subcutaneous administration of NTG (10 mg/kg) increases significantly the number of nNOS… CONTINUE READING