Cowpox virus inhibits the transporter associated with antigen processing to evade T cell recognition.

@article{Alzhanova2009CowpoxVI,
  title={Cowpox virus inhibits the transporter associated with antigen processing to evade T cell recognition.},
  author={Dina Alzhanova and David M. Edwards and Erika K Hammarlund and Isabel G Scholz and Dani{\"e}lle Horst and Mary J. Wagner and Chris Upton and Emmanuel J. H. J. Wiertz and Mark K. Slifka and Klaus Fr{\"u}h},
  journal={Cell host & microbe},
  year={2009},
  volume={6 5},
  pages={433-45}
}
Cowpox virus encodes an extensive array of putative immunomodulatory proteins, likely contributing to its wide host range, which includes zoonotic infections in humans. Unlike Vaccinia virus, cowpox virus prevents stimulation of CD8(+) T cells, a block that correlated with retention of MHC class I in the endoplasmic reticulum by the cowpox virus protein CPXV203. However, deletion of CPXV203 did not restore MHC class I transport or T cell stimulation. Here, we demonstrate the contribution of an… CONTINUE READING