Cow’s Milk Allergy: A Complex Disorder

  title={Cow’s Milk Allergy: A Complex Disorder},
  author={Ross G. Crittenden and Louise E. Bennett},
  journal={Journal of the American College of Nutrition},
  pages={582S - 591S}
Cow’s milk allergy (CMA) is a complex disorder. Numerous milk proteins have been implicated in allergic responses and most of these have been shown to contain multiple allergenic epitopes. There is considerable heterogeneity amongst allergic individuals for the particular proteins and epitopes to which they react, and to further complicate matters, allergic reactions to cow’s milk are driven by more than one immunological mechanism. Finally, the incidence and dominant allergic mechanisms change… 

Characteristics of patients suffering from cow milk allergy.

The immunopathogenesis of cow’s milk protein allergy (CMPA)

The immunopathogenetic aspects of CMPA are described in view of these new discoveries in the Immunologic field, considering the immunologic pathway at the basis of both IgE- and not-IgE mediated CMPA.

How Compatible is Cow’s Milk with the Human Immune System?

Cow’s milk has been part of the human diet for at least 8,000 years and provides a rich source of proteins, lipids, vitamins, and minerals. Despite its longstanding importance in human nutrition,

Immunological Analysis of Different Food Allergens-A Review

This report emphasis on allergens from peanut, wheat, cow milk, soy, egg and shellfish; and their pathophysiology, diagnosis, and management and its immunological mechanisms.

Treatment of Cow's Milk Protein Allergy

A systematic literature search was performed using Embase, Medline, The Cochrane Database of Systematic Reviews and Cochrane Central Register of Controlled Clinical Trials for the diagnosis and treatment of cow's milk allergy (CMA).

Variations in T-Cell Response Among Cow’s Milk Allergy Children With Or Without Sensitization to Casein Protein

Findings preliminarily revealed that a distinctive T cell mediated immune response among CMA patient with the different sensitized component is revealed.


“Adverse reactions to cow’s milk should be differentiated into immunologic (cow’s milk allergy) and non immunologic (cow’s milk intolerance)” [2]. “The most common cause of cow’s milk intolerance is



Cow's milk allergy: a new understanding from immunology.

  • J. Walker-Smith
  • Medicine
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
  • 2003

The natural history of cow's milk protein allergy/intolerance.

The findings of specific IgE to individual cow's milk proteins in cord blood of the majority of infants who later develop CMPA/CMPI suggests a prenatal sensitization may play a role in the pathogenesis of CMPA, and CMPA cannot be ruled out unless extensive diagnostic tests for type II-III-IV reactions have proved negative.

Cow-milk allergy.

  • E. Isolauri
  • Medicine
    Environmental toxicology and pharmacology
  • 1997

Prevalence of food allergies in young adults and their relationship to asthma, nasal allergies, and eczema.

Cow's milk protein allergy and possible means for its prevention.

Anaphylaxis to cow's milk and beef meat proteins.

  • P. Eigenmann
  • Medicine
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
  • 2002

IgE and non-IgE food allergy.

IgE and IgG Binding Epitopes on α-Lactalbumin and β-Lactoglobulin in Cow’s Milk Allergy

The usefulness of IgE binding to distinct epitopes on whey proteins in defining the patients that would have a lifelong CMA needs to be investigated in further studies.

Clinical course of cow's milk protein allergy/intolerance and atopic diseases in childhood

Children with non‐IgE‐mediated CMPI had a good prognosis, whereas children with IgE‐ mediated CMPA in early childhood had a significantly increased risk for persistent CMPA, development of other food allergies, asthma and rhinoconjunctivitis.

Formula feeding during cow's milk allergy.

Any elimination diet in children is at risk of nutritional deficiency so that a constant monitoring of the growth parameters should be kept in those children, especially for those below the age of 6 months.