Cow’s Milk Allergy: A Complex Disorder

@article{Crittenden2005CowsMA,
  title={Cow’s Milk Allergy: A Complex Disorder},
  author={R. Crittenden and L. Bennett},
  journal={Journal of the American College of Nutrition},
  year={2005},
  volume={24},
  pages={582S - 591S}
}
Cow’s milk allergy (CMA) is a complex disorder. Numerous milk proteins have been implicated in allergic responses and most of these have been shown to contain multiple allergenic epitopes. There is considerable heterogeneity amongst allergic individuals for the particular proteins and epitopes to which they react, and to further complicate matters, allergic reactions to cow’s milk are driven by more than one immunological mechanism. Finally, the incidence and dominant allergic mechanisms change… Expand
Position document: IgE-mediated cow's milk allergy.
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An update on the recommendations for managing patients with cow's milk allergy - a disorder that manifests in the first year of life, with an estimated prevalence of 1.6-3% in this paediatric age group is offered. Expand
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TLDR
The data showed that both cow milk-specific IgG and IgE levels were significantly elevated in CMA patients compared to those of age-matched control subjects, and the aberrant changes in the concentration of cow Milk Milk IgE antibodies were associated with cow Milk milk- specific IgG antibodies. Expand
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The most frequent symptoms among the manifestations of cow milk protein allergy (CMPA) are gastrointestinal. CMPA pathogenesis involves immunological mechanisms with participation of immunocompetentExpand
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TLDR
A systematic literature search was performed using Embase, Medline, The Cochrane Database of Systematic Reviews and Cochrane Central Register of Controlled Clinical Trials for the diagnosis and treatment of cow's milk allergy (CMA). Expand
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TLDR
Findings preliminarily revealed that a distinctive T cell mediated immune response among CMA patient with the different sensitized component is revealed. Expand
MILK AND DAIRY THREATS
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Contribution of IgE and immunoglobulin free light chain in the allergic reaction to cow's milk proteins.
TLDR
It is indicated that sensitization with cow's milk proteins can lead to both IgE-dependent and Ig-fLC-dependent allergic hypersensitivity responses, and in children affected with CMA or AD, serum Ig-FLC concentrations were increased, implying the relevance of Ig- fLC measurements in the diagnoses of human allergic disease. Expand
Is Cow's Milk Harmful to a Child's Health?
TLDR
Its protein and fat composition, together with the micronutrient content, is suggestive of a functional food, whose positive effects are emphasised by regular consumption, particularly under conditions of diets poor in some limiting nutrients, although in industrialised countries cow's milk's optimal daily intake should be around 500 mL, adequately complemented with other relevant nutrients. Expand
Cow's milk allergy in multiple sclerosis patients
TLDR
There was no difference between MS and healthy subjects regarding CMA, and there was no detection of cow's milk specific IgE in serum of MS patients andhealthy subjects. Expand
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References

SHOWING 1-10 OF 114 REFERENCES
Cow's milk allergy: a new understanding from immunology.
  • J. Walker-Smith
  • Medicine
  • Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
  • 2003
TLDR
It is demonstrated that the clinical manifestations of cow's milk allergy are very diverse, with differences between developing and developed countries, and understanding the immunologic mechanisms is of key importance in understanding this diversity. Expand
The natural history of cow's milk protein allergy/intolerance.
TLDR
The findings of specific IgE to individual cow's milk proteins in cord blood of the majority of infants who later develop CMPA/CMPI suggests a prenatal sensitization may play a role in the pathogenesis of CMPA, and CMPA cannot be ruled out unless extensive diagnostic tests for type II-III-IV reactions have proved negative. Expand
Cow-milk allergy.
  • E. Isolauri
  • Medicine
  • Environmental toxicology and pharmacology
  • 1997
TLDR
New approaches are urgently needed for the management of patients with cow-milk allergy, and may include: (i) immunotherapy to counteract the immunological dysfunction, and (ii) stabilisation of the gut mucosal barrier to strengthen endogenous defence mechanisms. Expand
Prevalence of food allergies in young adults and their relationship to asthma, nasal allergies, and eczema.
TLDR
Those with probable IgE peanut and shrimp allergy were significantly more likely to have current asthma and doctor-diagnosed asthma, and Wheeze and history of eczema were also associated with peanut allergy, whereas nasal allergies were associated with shrimp allergy. Expand
Cow's milk protein allergy and possible means for its prevention.
TLDR
The hygiene and gut-flora hypotheses assume that normal intestinal flora play a major role in the early development of the immune system and oral tolerance and if the Th1 cytokine system is insufficiently stimulated by viral and bacterial infections, the balance may be lost in favor of the Th2 system. Expand
Anaphylaxis to cow's milk and beef meat proteins.
  • P. Eigenmann
  • Medicine
  • Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
  • 2002
TLDR
In the absence of a proactive treatment of food allergy, patients with anaphylaxis to cow's milk or beef must be instructed to avoid these foods in their diet. Expand
IgE and non-IgE food allergy.
TLDR
The clinical manifestations of FA may be the result of immunologic injury mediated by interaction of food antigens with contiguous elements of mucosal associated lymphoid tissue, modulated by relative imbalances of the Th1/Th2 paradigm. Expand
IgE and IgG Binding Epitopes on α-Lactalbumin and β-Lactoglobulin in Cow’s Milk Allergy
Background: Cow’s milk is one of the most common causes of food allergy in the first years of life. We recently defined IgE and IgG binding epitopes for αs1-casein, a major cow’s milk allergen, andExpand
Clinical course of cow's milk protein allergy/intolerance and atopic diseases in childhood
TLDR
Children with non‐IgE‐mediated CMPI had a good prognosis, whereas children with IgE‐ mediated CMPA in early childhood had a significantly increased risk for persistent CMPA, development of other food allergies, asthma and rhinoconjunctivitis. Expand
Formula feeding during cow's milk allergy.
TLDR
Any elimination diet in children is at risk of nutritional deficiency so that a constant monitoring of the growth parameters should be kept in those children, especially for those below the age of 6 months. Expand
...
1
2
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