Covid-19: Ivermectin’s politicisation is a warning sign for doctors turning to orphan treatments

  title={Covid-19: Ivermectin’s politicisation is a warning sign for doctors turning to orphan treatments},
  author={Bibi-Aisha Wadvalla},
The drug ivermectin has divided the medical community in South Africa and elsewhere, with some arguing it can both prevent and treat covid-19. Bibi-Aisha Wadvalla explains how the case encapsulates the central argument when it comes to orphan treatments: do doctors or scientists know best? 
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  • Biology, Medicine
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  • 2011
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