Covid-19: Ivermectin’s politicisation is a warning sign for doctors turning to orphan treatments

  title={Covid-19: Ivermectin’s politicisation is a warning sign for doctors turning to orphan treatments},
  author={Bibi-Aisha Wadvalla},
The drug ivermectin has divided the medical community in South Africa and elsewhere, with some arguing it can both prevent and treat covid-19. Bibi-Aisha Wadvalla explains how the case encapsulates the central argument when it comes to orphan treatments: do doctors or scientists know best? 
Understanding ivermectin
George Winter examines the ongoing discussion as to whether invermectin can be used in the treatment of COVID-19, breaking down opposing viewpoints, the integrity of research, and the need for
Social Media and COVID-19—Perceptions and Public Deceptions of Ivermectin, Colchicine and Hydroxychloroquine: Lessons for Future Pandemics
Evidence of social media as a driver of re-purposed medicines is provided, with a spike in ivermectin use closely correlated to social media posts, and the majority of reporters in social media were unidentifiable.
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Encouraging to see low hospitalisation rates and limited use of antimicrobials apart from antibiotics, and concerns with high empiric use of antibiotics and limited switching to oral formulations can be addressed by instigating antimicrobial stewardship programmes.
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This study provides evidence regarding increased demand, online availability and consumer accessibility of ivermectin, an anthelmintic agent, without substantiated indications in reference to SARS-CoV-2, and illustrates connection between infodemic and its consequences on the illicit online pharmacy market.
Management of Children Admitted to Hospitals across Bangladesh with Suspected or Confirmed COVID-19 and the Implications for the Future: A Nationwide Cross-Sectional Study
It was encouraging to see the low hospitalisation rates and limited use of antimalarials, antivirals and antiparasitic medicines, however, the high empiric use of antibiotics, alongside limited switching to oral formulations, is a concern that can be addressed by instigating the appropriate programmes.


Covid-19: Convalescent plasma may cut deaths in patients not on ventilation, study indicates
InAugust 2020 theUSFood andDrugAdministration approved convalescent plasma for emergency use in hospital patientswith covid-19 despitewarnings over lack of evidence from randomised controlled
Meta-analysis of randomized trials of ivermectin to treat SARS-CoV-2 infection
Ivermectin should be validated in larger, appropriately controlled randomized trials before the results are sufficient for review by regulatory authorities.
Effect of Ivermectin on Time to Resolution of Symptoms Among Adults With Mild COVID-19: A Randomized Clinical Trial.
Among adults with mild COVID-19, a 5-day course of ivermectin, compared with placebo, did not significantly improve the time to resolution of symptoms, and the findings do not support the use of iVermectIn for treatment of mild CO VID-19.
Efficacy and safety of Ivermectin and Hydroxychloroquine in patients with severe COVID-19. A randomized controlled trial
In non-critical hospitalized patients with COVID-19 pneumonia, neither ivermectin nor hydroxychloroquine decreases the number of in-hospital days, respiratory deterioration, or deaths.
Ivermectin in COVID-19 Related Critical Illness
In COVID-19 illness, critically ill patients with lung injury requiring mechanical ventilation may benefit from administration of Ivermectin, and it is noted a lower mortality and reduced healthcare resource use in those treated with ivermECTin.
Ivermectin, ‘Wonder drug’ from Japan: the human use perspective
  • A. Crump, S. Ōmura
  • Political Science
    Proceedings of the Japan Academy. Series B, Physical and biological sciences
  • 2011
This paper looks in depth at the events surrounding ivermectin’s passage from being a huge success in Animal Health into its widespread use in humans, a development which has led many to describe it as a “wonder” drug.
COVID-19 update: Ivermectin. REBEL EM. Emergency medicine blog 16
    National Institute for Health and Care Excellence. COVID-19 rapid guideline: vitamin D. NICE Guidance NG187
      Why you should not use ivermectin to treat or prevent COVID-19