Covid-19: Convalescent plasma may cut deaths in patients not on ventilation, study indicates

@article{Wise2021Covid19CP,
  title={Covid-19: Convalescent plasma may cut deaths in patients not on ventilation, study indicates},
  author={J. Wise},
  journal={BMJ},
  year={2021},
  volume={372}
}
InAugust 2020 theUSFood andDrugAdministration approved convalescent plasma for emergency use in hospital patientswith covid-19 despitewarnings over lack of evidence from randomised controlled trials.2 3 A randomised controlled trial from India published in The BMJ in November found that convalescent plasma was not associated with a reduction in progression to severe covid-19 or in mortality from all causes.4 
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Convalescent plasma in the management of moderate covid-19 in adults in India: open label phase II multicentre randomised controlled trial (PLACID Trial)
TLDR
This trial has high generalisability and approximates convalescent plasma use in real life settings with limited laboratory capacity and was not associated with a reduction in progression to severe covid-19 or all cause mortality. Expand
Convalescent Plasma Antibody Levels and the Risk of Death from Covid-19
TLDR
Among patients hospitalized with Covid-19 who were not receiving mechanical ventilation, transfusion of plasma with higher anti–SARS-CoV-2 IgG antibody levels was associated with a lower risk of death than transfusionOf plasma with lower antibody levels. Expand