Coverage and consistency: bioinformatics aspects of the analysis of multirun iTRAQ experiments with wheat leaves.

@article{Pascovici2013CoverageAC,
  title={Coverage and consistency: bioinformatics aspects of the analysis of multirun iTRAQ experiments with wheat leaves.},
  author={Dana Pascovici and Donald M Gardiner and Xiaomin Song and Edmond Breen and Peter S. Solomon and Tim Keighley and Mark P. Molloy},
  journal={Journal of proteome research},
  year={2013},
  volume={12 11},
  pages={4870-81}
}
The hexaploid genome of bread wheat (Triticum aestivum) is large (17 Gb) and repetitive, and this has delayed full sequencing and annotation of the genome, which is a prerequisite for effective quantitative proteomics analysis. Aware of these constraints we investigated the most effective approaches for shotgun proteomic analyses of bread wheat that would support large-scale quantitative comparisons using iTRAQ reagents. We used a data set that was generated by two-dimensional LC-MS of iTRAQ… CONTINUE READING
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