Covariate-based constrained randomization of group-randomized trials.

  title={Covariate-based constrained randomization of group-randomized trials.},
  author={Lawrence H. Moulton},
  journal={Clinical trials},
  volume={1 3},
Group-randomized study designs are useful when individually randomized designs are either not possible, or will not be able to estimate the parameters of interest. Blocked and/or stratified (for example, pair-matched) designs have been used, and their properties statistically evaluated by many researchers. Group-randomized trials often have small numbers of experimental units, and strong, geographically induced between-unit correlation, which increase the chance of obtaining a "bad… CONTINUE READING

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