Covariate adjustment for two-sample treatment comparisons in randomized clinical trials: a principled yet flexible approach.

@article{Tsiatis2008CovariateAF,
  title={Covariate adjustment for two-sample treatment comparisons in randomized clinical trials: a principled yet flexible approach.},
  author={Anastasios A. Tsiatis and M. Davidian and Min Zhang and Xiaomin Lu},
  journal={Statistics in medicine},
  year={2008},
  volume={27 23},
  pages={4658-77}
}
There is considerable debate regarding whether and how covariate-adjusted analyses should be used in the comparison of treatments in randomized clinical trials. Substantial baseline covariate information is routinely collected in such trials, and one goal of adjustment is to exploit covariates associated with outcome to increase precision of estimation of the treatment effect. However, concerns are routinely raised over the potential for bias when the covariates used are selected post hoc and… CONTINUE READING