Covalently bound omega-hydroxyacylsphingosine in the stratum corneum.

  title={Covalently bound omega-hydroxyacylsphingosine in the stratum corneum.},
  author={Philip W Wertz and Donald T. Downing},
  journal={Biochimica et biophysica acta},
  volume={917 1},
Pig epidermis was heat separated, and the stratum corneum was isolated after trypsinization. Exhaustive extraction of the stratum corneum fraction with chloroform/methanol mixtures yielded 14.7% lipid on a dry weight basis. After mild saponification of the extracted residue, additional lipid could be extracted which accounted for 2.1% of the stratum corneum weight. This bound lipid proved to consist mainly (91.9%) of N-(omega-hydroxyacyl)sphingosines in which the amide-linked omega-hydroxyacids… CONTINUE READING

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