Covalent virus layer for mass-based biosensing.

  title={Covalent virus layer for mass-based biosensing.},
  author={L. Yang and Juan Esteban Diaz and Theresa M. McIntire and Gregory A. Weiss and Reginald M Penner},
  journal={Analytical chemistry},
  volume={80 4},
M13 virus particles were covalently attached to a planar gold-coated quartz crystal microbalance (QCM) through reaction with a self-assembled monolayer of N-hydroxysuccinimide thioctic ester, followed by incorporation of the blocking agent bovine serum albumin. This immobilization chemistry produced a phage multilayer having a coverage equivalent to approximately 6.5 close-packed monolayers of the virus. The properties of this "covalent virus surface" or CVS for the mass-based detection of a… CONTINUE READING
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