Covalent inactivation of factor VIII antibodies from hemophilia A patients by an electrophilic FVIII Analog.

Abstract

The antigen-binding sites of antibodies (Abs) can express enzyme-like nucleophiles that react covalently with electrophilic compounds. We examined the irreversible and specific inactivation of antibodies (Abs) to Factor VIII (FVIII) responsible for failure of FVIII replacement therapy in hemophilia A (HA) patients. Electrophilic analogs of FVIII (E-FVIII… (More)
DOI: 10.1074/jbc.M800589200

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@article{Planque2008CovalentIO, title={Covalent inactivation of factor VIII antibodies from hemophilia A patients by an electrophilic FVIII Analog.}, author={Stephanie A Planque and Miguel Angel Escobar and Keri C. Smith and Hiroaki Taguchi and Yasuhiro Nishiyama and Elizabeth M. Donnachie and Kathleen P Pratt and Sudhir Paul}, journal={The Journal of biological chemistry}, year={2008}, volume={283 18}, pages={11876-86} }