Covalent growth factor tethering to direct neural stem cell differentiation and self-organization.

@article{Ham2017CovalentGF,
  title={Covalent growth factor tethering to direct neural stem cell differentiation and self-organization.},
  author={Trevor R. Ham and Mahmoud Mahrous Sayed Farrag and Nic D Leipzig},
  journal={Acta biomaterialia},
  year={2017},
  volume={53},
  pages={140-151}
}
Tethered growth factors offer exciting new possibilities for guiding stem cell behavior. However, many of the current methods present substantial drawbacks which can limit their application and confound results. In this work, we developed a new method for the site-specific covalent immobilization of azide-tagged growth factors and investigated its utility in a model system for guiding neural stem cell (NSC) behavior. An engineered interferon-γ (IFN-γ) fusion protein was tagged with an N… CONTINUE READING
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