Covalent coupling of vitamin D3 to the major cat allergen Fel d 1 improves the effects of allergen-specific immunotherapy in a mouse model for cat allergy.

@article{Grundstrm2012CovalentCO,
  title={Covalent coupling of vitamin D3 to the major cat allergen Fel d 1 improves the effects of allergen-specific immunotherapy in a mouse model for cat allergy.},
  author={Jeanette Grundstr{\"o}m and Theresa Neimert-Andersson and Cecilia Kemi and Ola B. Nilsson and Tiiu Saarne and Mats A Andersson and Marianne van Hage and Guro Gafvelin},
  journal={International archives of allergy and immunology},
  year={2012},
  volume={157 2},
  pages={
          136-46
        }
}
BACKGROUND Allergen-specific immunotherapy (SIT) is currently the only curative treatment for allergy but the treatment needs to be improved. We hypothesize that covalent coupling of immunomodulating vitamin D3 to the major cat allergen Fel d 1 can enhance the beneficial effects of SIT to cat allergy. METHODS We treated mice sensitized to Fel d 1 with subcutaneous injections of two doses of recombinant Fel d 1 coupled to 1α,25-dihydroxyvitamin D3 (rFel d 1:VD3) and compared to treatment with… CONTINUE READING

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[Vitamin D in allergic disorders].

Postepy higieny i medycyny doswiadczalnej • 2014
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Hypoallergenic derivatives of Fel d 1 obtained by rational reassembly for allergy vaccination and tolerance induction.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology • 2014
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