Covalent coupling of asparagus pea and tomato lectins to poly(lactide) microspheres.

@article{Montisci2001CovalentCO,
  title={Covalent coupling of asparagus pea and tomato lectins to poly(lactide) microspheres.},
  author={M J Montisci and Gaetana Giovannuci and Dominique Duch{\^e}ne and Gilles Ponchel},
  journal={International journal of pharmaceutics},
  year={2001},
  volume={215 1-2},
  pages={153-61}
}
Lectin-poly(lactide) microsphere conjugates specifically designed for oral administration were prepared and their activity and specificity in presence of mucus were characterized. The presence of hydroxyl or amino groups suitable for covalent coupling of lectins by the glutaraldehyde method at the surface of the microspheres have been ensured by preparing the particles in presence either of poly(vinyl alcohol) (PVA) or bovine serum albumin (BSA). Tomato and asparagus pea lectins could be… CONTINUE READING

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