Covalent complexes of albumin with serotonin, ketanserin and lysergic acid antagonize the activity of serotonin in human platelets.

@article{Vandenberg1989CovalentCO,
  title={Covalent complexes of albumin with serotonin, ketanserin and lysergic acid antagonize the activity of serotonin in human platelets.},
  author={Scott R. Vandenberg and Steven L Gonias},
  journal={Life sciences},
  year={1989},
  volume={44 23},
  pages={
          1777-85
        }
}
Covalent conjugates of bovine serum albumin (BSA) and 5-HT, ketanserin or d-lysergic acid were synthesized and characterized by polyacrylamide gel electrophoresis, whole blood clearance experiments in mice and aggregation studies with human platelets. Using the standard synthesis procedure, each mol of BSA bound 13.4 mol of [3H]5-HT. Derivatization did not… CONTINUE READING