Corpus ID: 21981673

Covalent binding of two pyrrolizidine alkaloids, senecionine and seneciphylline, to hepatic macromolecules and their distribution, excretion, and transfer into milk of lactating mice.

@article{Eastman1982CovalentBO,
  title={Covalent binding of two pyrrolizidine alkaloids, senecionine and seneciphylline, to hepatic macromolecules and their distribution, excretion, and transfer into milk of lactating mice.},
  author={D. Eastman and G. P. Dimenna and H. J. Segall},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1982},
  volume={10 3},
  pages={
          236-40
        }
}

D. Eastman, G. P. Dimenna, H. J. Segall

Published 1982

Chemistry, Medicine

Drug metabolism and disposition: the biological fate of chemicals

Two macrocyclic 14C-pyrrolizidine alkaloids (PA's), senecionine an seneciphylline, were studied regarding the distribution, excretion, transfer into milk, and covalent binding to hepatic macromolecules in BALB/c mice. After injection, radioactivity was rapidly excreted in the urine and feces (84% or greater) within 16 hr. The liver contained over 1.5% of the dose at 16 hr. A small amount, 0.04%, of the dose was transferred into the milk in 16 hr; the majority of radioactivity was found in the… CONTINUE READING

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