Covalent binding of styrene to DNA in rat and mouse.

@article{Cantoreggi1993CovalentBO,
  title={Covalent binding of styrene to DNA in rat and mouse.},
  author={S Cantoreggi and W K Lutz},
  journal={Carcinogenesis},
  year={1993},
  volume={14 3},
  pages={355-60}
}
Covalent binding of [7-3H]styrene (S) to DNA in vivo was measured and evaluated in a quantitative manner in order to investigate whether DNA adduct formation could form a mechanistic basis for tumor induction in a carcinogenicity bioassay. [7-3H]S was administered by inhalation in a closed chamber to male and female CD rats and B6C3F1 mice. After 4.5-6 h (rats) and 6-9 h (pools of four mice), S doses of 23-39 and 85-110 mg/kg respectively had been metabolized. DNA was purified to constant… CONTINUE READING
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