Covalent binding of styrene to DNA in rat and mouse.

  title={Covalent binding of styrene to DNA in rat and mouse.},
  author={S Cantoreggi and W K Lutz},
  volume={14 3},
Covalent binding of [7-3H]styrene (S) to DNA in vivo was measured and evaluated in a quantitative manner in order to investigate whether DNA adduct formation could form a mechanistic basis for tumor induction in a carcinogenicity bioassay. [7-3H]S was administered by inhalation in a closed chamber to male and female CD rats and B6C3F1 mice. After 4.5-6 h (rats) and 6-9 h (pools of four mice), S doses of 23-39 and 85-110 mg/kg respectively had been metabolized. DNA was purified to constant… CONTINUE READING
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Investigation of the covalent binding ofStyreno7 , 8oxide to DNA in n 11 and mouse

  • S. CanlOreggi, W. K. Lutz
  • CardrrogeMSi
  • 1992

Species diffe : rcnces in the geuoroxicity of cyclophosphamide and eyrene in thrce in l ' ivo assays

  • M. Sorsa, A. Anttila, +6 authors H. Vainio
  • MUlal . Res .
  • 1992

Effi : ct of inha 1 ation exposure regimcn on DN A binding potc : ncy of 1 , 2dkbloroetbane in the rat

  • A. Baertsclt, W. K. BDd Schlatttr Lutz, C.
  • 1991

Styrene revisitcd ~ posure assessment and risk cstimation in reinforced plastics industty

  • S. A. S. WaUes
  • Prog . Clin . Bio / . Re . r .
  • 1991

Identification of alkylation products of styrene oxide in singleand doublestrandcd DNA

  • K. Bergman
  • 1988

Tbe relevance of covalent binding to . mouse liver DNA to the carcinogenic action of bexachlorocyclohexane isomers

  • P. Sagdsdorff, W. K. aod Scblatter Lutz, C.
  • 1983

Reactioos of vinyt cbloride with RNA and DNA of varioos mause tissues in vim

  • L. S. Gold, C. B. Sawyer, +9 authors B. N. Amcs
  • A . rch . . Taricol .
  • 1982

4 - Vinylpheool excretion suggestive of arene oxide fonnation in workers occupationally exposcd to styreoe

  • P. Pfiffli, A. Hesso, H. Vainio, M. Hyvönen
  • 1981

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