Covalent binding of carbamazepine reactive metabolites to P450 isoforms present in the skin.

@article{Wolkenstein1998CovalentBO,
  title={Covalent binding of carbamazepine reactive metabolites to P450 isoforms present in the skin.},
  author={Pierre Wolkenstein and Chibing Tan and S. Lecoeur and Jeremy Wechsler and N Garcia-Martin and Dominique Charue and Martine Bagot and Philippe H. Beaune},
  journal={Chemico-biological interactions},
  year={1998},
  volume={113 1},
  pages={39-50}
}
Carbamazepine is an anticonvulsant associated with a high risk for severe cutaneous reactions. Upon metabolism by cytochrome P450, carbamazepine may produce reactive metabolites. We evaluated in vitro the covalent binding of carbamazepine reactive metabolites on human P450s and then the presence of these P450s in human epidermis. Carbamazepine reactive metabolites covalent binding to human liver microsomes involved P450 subfamilies 1A, 2C and 3A. Specific covalent binding to yeasts expressing… CONTINUE READING

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