Covalent binding of [14C]methoxychlor metabolite(s) to rat liver microsomal components.

Abstract

[14C]Methoxychlor was incubated with NADPH-fortified liver microsomes from male rats, and covalent binding to microsomal components was determined. The binding process was markedly enhanced when microsomes from phenobarbital-treated rats were employed. However, when microsomes from methylcholanthrene-treated rats were used the level of binding was not… (More)

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@article{Bulger1983CovalentBO, title={Covalent binding of [14C]methoxychlor metabolite(s) to rat liver microsomal components.}, author={W H Bulger and Joshua E Temple and David Jerome Kupfer}, journal={Toxicology and applied pharmacology}, year={1983}, volume={68 3}, pages={367-74} }