Covalent assembly of nanoparticles as a peptidase-degradable platform for molecular MRI

@inproceedings{PerezBalderas2017CovalentAO,
  title={Covalent assembly of nanoparticles as a peptidase-degradable platform for molecular MRI},
  author={Francisco Perez-Balderas and Sander I van Kasteren and Alaa A. A. Aljabali and Kim Wals and S{\'e}bastien Serres and Andrew Jefferson and Manuel Sarmiento Soto and Alexandre A. Khrapitchev and James R Larkin and Claire A Bristow and Seung Seo Lee and Guillaume Bort and Filippo De Simone and Sandra J. Campbell and Robin Patrick Choudhury and Daniel C. Anthony and Nicola R. Sibson and Benjamin G Davis},
  booktitle={Nature communications},
  year={2017}
}
Ligand-conjugated microparticles of iron oxide (MPIO) have the potential to provide high sensitivity contrast for molecular magnetic resonance imaging (MRI). However, the accumulation and persistence of non-biodegradable micron-sized particles in liver and spleen precludes their clinical use and limits the translational potential of MPIO-based contrast… CONTINUE READING