Covalent and injectable chitosan-chondroitin sulfate hydrogels embedded with chitosan microspheres for drug delivery and tissue engineering.

@article{Fan2017CovalentAI,
  title={Covalent and injectable chitosan-chondroitin sulfate hydrogels embedded with chitosan microspheres for drug delivery and tissue engineering.},
  author={Ming Yu Fan and Ye Yuan Ma and Huaping Tan and Yang Jia and Siyue Zou and Shuxuan Guo and Meng Zhao and Hao Huang and Zhonghua Ling and Yong Chen and Xiaohong Hu},
  journal={Materials science & engineering. C, Materials for biological applications},
  year={2017},
  volume={71},
  pages={
          67-74
        }
}
Injectable hydrogels and microspheres derived from natural polysaccharides have been extensively investigated as drug delivery systems and cell scaffolds. In this study, we report a preparation of covalent hydrogels basing polysaccharides via the Schiff' base reaction. Water soluble carboxymethyl chitosan (CMC) and oxidized chondroitin sulfate (OCS) were prepared for cross-linking of hydrogels. The mechanism of cross-linking is attributed to the Schiff' base reaction between amino and aldehyde… CONTINUE READING

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