Covalent adducts of melphalan with free amino acids and a model peptide studied by liquid chromatography/tandem mass spectrometry.

Abstract

RATIONALE Melphalan is a frequently used chemotherapeutical agent for the treatment of myeloma, breast cancer, ovarian cancer and sarcoma of soft tissue. A good knowledge of the reactivity of the drug toward the different amino acids, e.g. covalent adduct formation, is crucial for the understanding of its activity and side effects during cancer treatment… (More)
DOI: 10.1002/rcm.7489

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Cite this paper

@article{Dewaele2016CovalentAO, title={Covalent adducts of melphalan with free amino acids and a model peptide studied by liquid chromatography/tandem mass spectrometry.}, author={Debbie Dewaele and Frank Sobott and Filip Lemi{\`e}re}, journal={Rapid communications in mass spectrometry : RCM}, year={2016}, volume={30 6}, pages={719-30} }