CovS simultaneously activates and inhibits the CovR-mediated repression of distinct subsets of group A Streptococcus virulence factor-encoding genes.

@article{Trevio2009CovSSA,
  title={CovS simultaneously activates and inhibits the CovR-mediated repression of distinct subsets of group A Streptococcus virulence factor-encoding genes.},
  author={Jeanette Trevi{\~n}o and Nataly Perez and Esmeralda Ramirez-Pe{\~n}a and Zhuyun Liu and Samuel A. Shelburne and James M. Musser and Paul Sumby},
  journal={Infection and immunity},
  year={2009},
  volume={77 8},
  pages={3141-9}
}
To colonize and cause disease at distinct anatomical sites, bacterial pathogens must tailor gene expression in a microenvironment-specific manner. The molecular mechanisms that control the ability of the human bacterial pathogen group A Streptococcus (GAS) to transition between infection sites have yet to be fully elucidated. A key regulator of GAS virulence gene expression is the CovR-CovS two-component regulatory system (also known as CsrR-CsrS). covR and covS mutant strains arise… CONTINUE READING