CovR and VicRK Regulate Cell Surface Biogenesis Genes Required for Biofilm Formation in Streptococcus mutans

@inproceedings{Stipp2013CovRAV,
  title={CovR and VicRK Regulate Cell Surface Biogenesis Genes Required for Biofilm Formation in Streptococcus mutans},
  author={R N Stipp and Heike Boisvert and Daniel James Smith and Jos{\'e} Francisco H{\"o}fling and Margaret Carlisle Duncan and Renata O Mattos-Graner},
  booktitle={PloS one},
  year={2013}
}
The two-component system VicRK and the orphan regulator CovR of Streptococcus mutans co-regulate a group of virulence genes associated with the synthesis of and interaction with extracellular polysaccharides of the biofilm matrix. Knockout mutants of vicK and covR display abnormal cell division and morphology phenotypes, although the gene function defects involved are as yet unknown. Using transcriptomic comparisons between parent strain UA159 with vicK (UAvic) or covR (UAcov) deletion mutants… CONTINUE READING
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