CovR activation of the dipeptide permease promoter (PdppA) in Group A Streptococcus.

@article{Gusa2007CovRAO,
  title={CovR activation of the dipeptide permease promoter (PdppA) in Group A Streptococcus.},
  author={Asiya A Gusa and Barbara J. Froehlich and Devak G. Desai and Virginia A Stringer and June R. Scott},
  journal={Journal of bacteriology},
  year={2007},
  volume={189 4},
  pages={
          1407-16
        }
}
CovR, the two-component response regulator of Streptococcus pyogenes (group A streptococcus [GAS]) directly or indirectly represses about 15% of the genome, including genes encoding many virulence factors and itself. Transcriptome analyses also showed that some genes are activated by CovR. We asked whether the regulation by CovR of one of these genes, dppA, the first gene in an operon encoding a dipeptide permease, is direct or indirect. Direct regulation by CovR was suggested by the presence… CONTINUE READING

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