Course of transplanted Heymann nephritis kidney in normal host. Implications for mechanism of proteinuria in membranous glomerulonephropathy.

@article{Makker1989CourseOT,
  title={Course of transplanted Heymann nephritis kidney in normal host. Implications for mechanism of proteinuria in membranous glomerulonephropathy.},
  author={Sudesh Paul Makker and John J. Kanalas},
  journal={Journal of immunology},
  year={1989},
  volume={142 10},
  pages={3406-10}
}
Heymann nephritis [model of membranous glomerulonephropathy (MGN)] kidneys (n = 20) with proteinuria were transplanted into unilaterally nephrectomized normal syngeneic Lewis recipient rats to study the course of established MGN lesion in normal milieu. Concurrent with the loss of C3 staining from the MGN lesion at 2 to 4 wk after transplantation, the proteinuria decreased from the transplanted kidney (p less than 0.02). Thereafter, from 2 to 28 wk no further decrease was noted in proteinuria… CONTINUE READING
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