Course of illness, hippocampal function, and hippocampal volume in major depression.

  title={Course of illness, hippocampal function, and hippocampal volume in major depression.},
  author={Glenda M. MacQueen and Stephanie Campbell and Bruce S. McEwen and Kathryn Macdonald and Shigeko Amano and Russell T. Joffe and Claude Nahmias and Lionel Trevor Young},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={100 3},
Studies have examined hippocampal function and volume in depressed subjects, but none have systematically compared never-treated first-episode patients with those who have had multiple episodes. We sought to compare hippocampal function, as assessed by performance on hippocampal-dependent recollection memory tests, and hippocampal volumes, as measured in a 1.5-T magnetic resonance imager, in depressed subjects experiencing a postpubertal onset of depression. Twenty never-treated depressed… CONTINUE READING
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