Course of Tic Severity in Tourette Syndrome: The First Two Decades

@article{Leckman1998CourseOT,
  title={Course of Tic Severity in Tourette Syndrome: The First Two Decades},
  author={James Frederick Leckman and Heping Zhang and Amy Vitale and Fatima Lahnin and Kimberly A. Lynch and Colin M. Bondi and Young-Shin Kim and Bradley S. Peterson},
  journal={Pediatrics},
  year={1998},
  volume={102},
  pages={14 - 19}
}
Objective. Prevalence studies indicate a 10-fold higher rate of Tourette syndrome (TS) among children compared with adults. The purpose of this investigation was to examine the course of tic severity during the first 2 decades of life. Method. A birth-year cohort of 42 TS patients followed at the Yale Child Study Center was recontacted an average of 7.3 years after their initial clinical evaluation. Data concerning the onset and course of tic severity until 18 years of age were available on 36… 

Figures and Tables from this paper

Tic Exacerbation in Adults with Tourette Syndrome: A Case Series
TLDR
It is demonstrated that the decline in symptoms as patients age may represent temporary improvement, and the latent period lasted years in patients, different from the more rapid waxing and waning in children.
Review article Clinical course of Tourette syndrome
TLDR
Although tics are the sine qua non of TS, they are often not the most enduring or impairing symptoms in children with TS, and measures used to enhance selfesteem are crucial to ensuring positive adulthood outcome in TS.
Clinical course of Tourette syndrome.
Tic symptoms in Tourette's syndrome reached their worst level of severity in middle childhood and then declined
TLDR
Greater severity of tic symptoms during the worst ever period was associated with increasing age at the time of worst ever symptoms, and the onset of puberty was not associated with the timing or degree of best ever tic severity.
Course of Tourette Syndrome and Comorbidities in a Large Prospective Clinical Study.
Predictors of the Clinical Course of Tourette Syndrome: A Longitudinal Study
TLDR
Strong clinical predictors of Tourette syndrome–associated outcomes in early adulthood that are directly applicable to clinical Tourette Syndrome populations are identified and may help to guide new patients, plan early interventions, and implement preventive measures.
Clinical Features of Tourette Syndrome and Tic Disorders.
Reexamining Tic Persistence and Tic-Associated Impairment in Tourette's Disorder: Findings From a Naturalistic Follow-Up Study
TLDR
The view that Tourette's Disorder is a persistent disorder is supported, but a dissociation between tic persistence and tic-associated dysfunction is suggested.
Variables Associated with Increased Tic Severity in 5,500 Participants with Tourette Syndrome
TLDR
The attention-deficit hyperactivity disorder was not associated with tic severity but obsessive compulsive disorder was an important variable associated withTic severity.
...
...