Course of Improvement in Depressive Symptoms to a Single Intravenous Infusion of Ketamine vs Add-on Riluzole: Results from a 4-Week, Double-Blind, Placebo-Controlled Study

@article{Ibrahim2012CourseOI,
  title={Course of Improvement in Depressive Symptoms to a Single Intravenous Infusion of Ketamine vs Add-on Riluzole: Results from a 4-Week, Double-Blind, Placebo-Controlled Study},
  author={Lobna A Ibrahim and Nancy Diazgranados and Jos{\'e} A. Franco-Chaves and Nancy E. Brutsche and Ioline D. Henter and Phillip D Kronstein and Ruin Moaddel and Irving W Wainer and David A. Luckenbaugh and Husseini K. Manji and Carlos A. Zarate},
  journal={Neuropsychopharmacology},
  year={2012},
  volume={37},
  pages={1526-1533}
}
The N-methyl-D-aspartate antagonist ketamine has rapid antidepressant effects in patients with treatment-resistant major depression (TRD); these effects have been reported to last for 1 week in some patients. However, the extent and duration of this antidepressant effect over longer periods has not been well characterized under controlled conditions. Riluzole, a glutamatergic modulator with antidepressant and synaptic plasticity-enhancing effects, could conceivably be used to promote the… CONTINUE READING
Highly Influential
This paper has highly influenced 16 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Highly Cited
This paper has 217 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 110 extracted citations

Current Status of Ketamine and Related Therapies for Mood and Anxiety Disorders.

Current behavioral neuroscience reports • 2015
View 13 Excerpts
Highly Influenced

Concomitant BDNF and sleep slow wave changes indicate ketamine-induced plasticity in major depressive disorder.

The international journal of neuropsychopharmacology • 2013
View 4 Excerpts
Highly Influenced

Ketamine and other potential glutamate antidepressants

Psychiatry Research • 2015
View 7 Excerpts
Highly Influenced

A review of ketamine’s role in ECT and non-ECT settings

Neuropsychiatric disease and treatment • 2018
View 4 Excerpts
Highly Influenced

Characterizing the course of suicidal ideation response to ketamine.

Journal of affective disorders • 2018
View 4 Excerpts
Highly Influenced

217 Citations

02040'13'15'17'19
Citations per Year
Semantic Scholar estimates that this publication has 217 citations based on the available data.

See our FAQ for additional information.

References

Publications referenced by this paper.
Showing 1-10 of 33 references

The assessment of anxiety states by rating

M Hamilton
Br J Med Psychol • 1959
View 6 Excerpts
Highly Influenced

A rating scale for mania: reliability, validity and sensitivity.

The British journal of psychiatry : the journal of mental science • 1978
View 4 Excerpts
Highly Influenced

Assessment of depression: the depression inventory.

Modern problems of pharmacopsychiatry • 1974
View 5 Excerpts
Highly Influenced

A rating scale for depression.

Journal of neurology, neurosurgery, and psychiatry • 1960
View 6 Excerpts
Highly Influenced