Patients treated with paroxetine had shorter treatment duration ( 157.0 days ) than did patients treated with fluoxetine ( 192.6 days ) or sertraline ( 166.9 days , P < 0.001 ) .
During this study period when fluoxetine , paroxetine , and sertraline were all well - established agents , similar depression - related treatment courses and cost characteristics among all 3 drugs were observed .
Mean antidepressant prescription costs differed , being $ 586 , $ 419 , and $ 446 for fluoxetine , paroxetine and sertraline cohorts , respectively ( P < 0.001 ) .
Patients receiving index treatment with paroxetine were most likely to switch to another SSRI ( 21.3% ) ; those taking sertraline were second most likely to switch ( 16.1% ) ; and those on fluoxetine were least likely ( 12.4% , P = 0.001 ) .
Nine - hundred five ( 905 ) patients taking sertraline , 492 on paroxetine , and 945 on fluoxetine met inclusion criteria .
To compare depression - related treatment costs and total healthcare costs for patients diagnosed with depression and treated with either sertraline , paroxetine , or fluoxetine .
Course and cost of treatment for depression with fluoxetine , paroxetine , and sertraline . OBJECTIVE .