Coupling transcriptional and post-transcriptional miRNA regulation in the control of cell fate

@inproceedings{Shalgi2009CouplingTA,
  title={Coupling transcriptional and post-transcriptional miRNA regulation
                        in the control of cell fate},
  author={Reut Shalgi and Ran Brosh and Moshe Oren and Yitzhak Pilpel and Varda Rotter},
  booktitle={Aging},
  year={2009}
}
miRNAs function as a critical regulatory layer in development, differentiation, and the maintenance of cell fate. Depletion of miRNAs from embryonic stem cells impairs their differentiation capacity. Total elimination of miRNAs leads to premature senescence in normal cells and tissues through activation of the DNA-damage checkpoint, whereas ablation of miRNAs in cancer cell lines results in an opposite effect, enhancing their tumorigenic potential. Here we compile evidence from the literature… CONTINUE READING

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The impact of microRNAs on protein output

  • MT Hemann, Hernando ‐ Monge, +5 authors Hammond
  • 2008

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